Publications by authors named "D Wirthner"

The acceptance of "marriage for all" in Switzerland has enabled married couples to have access to medically assisted reproduction (MAR) through sperm donation from July 2022. We present the Swiss legal context of sperm donation, the different techniques, the selection of donors and the method of attribution to recipient couples. This article also describes the complexities of managing a sperm bank in Switzerland, presents some of the figures associated and address the fundamental question of access to origins and the secrecy that may be linked to sperm donation.

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In Europe, assisted reproductive technology (ART) is monitored in national registers but the definitions used and the recorded data vary from one register to another. In order to provide the stakeholders in this field with the most useful information and avoid an intolerable administrative burden for individual clinics, it is important to agree what constitutes core data for national registers. To do this, experts from 24 European countries met in March 2007 in Lausanne under the auspices of the Fondation pour l'Andrologie, la Biologie et l'Endocrinologie de la Reproduction (FABER) to discuss what constitutes core data for national assisted reproductive technology (ART) registers.

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Background/aims: Endocrine features of polycystic ovary syndrome (PCOS) include altered ovarian steroidogenesis, hyperinsulinemia and abnormal luteinizing hormone (LH) secretion. This study was undertaken to further evaluate the role of insulin to modulate LH secretion in lean PCOS patients with normal insulin sensitivity and normal volunteers.

Methods: The study was performed in five nonobese patients diagnosed with PCOS on the basis of amenorrhea and a polycystic morphology at ovarian ultrasound, and 5 normal controls in early to mid-follicular phase and matched for weight and age.

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Article Synopsis
  • Swiss law prohibits embryo selection, so a new scoring system is needed to identify zygotes with high implantation potential for either fresh transfer or cryopreservation.
  • A cumulated pronuclear score (CPNS) was developed based on factors like pronuclei position and cytoplasmic halo from both fresh and frozen-thawed zygotes, finding a positive correlation with implantation success.
  • Although frozen zygotes generally had a lower CPNS and lower pregnancy rates, they could still achieve successful implantation after thawing, suggesting that some may recover from freezing damage.
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Cervical cancer results from cervical infection by human papillomaviruses (HPV), especially HPV16. Previous studies have shown that intramuscular vaccination of women with an HPV16 virus-like particle (VLP) vaccine induced a strong IgG response and protected against genital HPV16 infection. However, an alternative route of administration that avoids parenteral injection while inducing mucosal immunity might facilitate vaccine implementation in some settings, and partially overcome the substantial variation in HPV16 antibodies at the cervix seen in ovulating women.

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