Characterization of outcomes in patients with advanced genitourinary malignancies treated with immune checkpoint inhibitors.

Purpose: Several immune checkpoint inhibitors (ICIs) are FDA approved for treatment of genitourinary (GU) malignancies. We aim to determine demographic and clinicopathologic characteristics that significantly affect clinical outcomes in patients with advanced stage GU malignancies treated with ICIs.

Materials And Methods: We performed a single-center, consecutive, retrospective cohort analysis on patients with metastatic or unresectable GU malignancies who were treated with ICIs at the University of Michigan.

"Live, Learn and Play": building strategic alliances between professional sports and public health.

Public-private partnerships allow communities and corporate entities to pool resources to address a mission of relevance to their common constituency or consumer base. Collaborations between public health and professional sports may present unique opportunities to improve health outcomes related to physical activity since athletes are fitness icons, both for adults and children. There are many "win-win" opportunities, as sports venues regularly host huge numbers of spectators, offering food and entertainment, providing hours of exposure, and introducing new ideas for engaging fans in order to remain a competitive draw.

Time perspective as a potential tool for psychotherapeutic intervention.

This pilot study shows (1) similarities among adults in the patterns of organization of the past, present, and future based upon individual imagery and spatial representation of their personal perspective of their lives and (2) a relationship between perceived health and future-orientation, i.e., how far into their future a person imagines self still to be alive.

Audit of bone marrow aspirates and trephine biopsies in multiple myeloma--a single centre study.

We compared 79 simultaneous marrow aspirates and trephine biopsies from multiple myeloma patients for sensitivity, concordance, quality and clinical relevance. A total of 60 examinations had been performed for initial diagnosis, i.e.