Publications by authors named "D Windt"
As important immune regulatory cells, whether innate lymphoid cells (ILCs) are involved in liver transplantation (LT) remains unclear. In a murine orthotopic LT model, we dissected roles of ILCs in liver ischemia-reperfusion injury (IRI). Wild type (WT) grafts suffered significantly higher IRI in Rag2-γc double knockout (DKO) than Rag2 KO recipients, in association with downregulation of group 1 ILCs genes, including IFN-γ.
View Article and Find Full Text PDFBackground: There is increasing burden on musculoskeletal (MSK) First Contact Practitioners (FCPs) working in primary care. One possible solution is to use digital technologies such as clinical decision support systems (CDSS). The primary objective of this study was to understand the potential for MSK FCPs to use a CDSS to support their practice in the United Kingdom.
View Article and Find Full Text PDFObjective: We conducted a longitudinal observational study over 11 years to identify the risk factors for developing shoulder pain, stiffness, or both.
Method: The study population (n = 1645) was identified from Health 2000 Survey, a nationally representative sample of Finns aged ≥ 44 years, without shoulder pain and stiffness at the start of the study based on a questionnaire. The independent variables included age, sex, body mass index (BMI), education level, diabetes, physical work exposures, and Beck's depression score.
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project).
Pain
October 2024
Article Synopsis
- The SupportPrim PT clinical decision support system (CDSS) was developed using artificial intelligence to help personalize musculoskeletal pain management and was evaluated through a cluster-randomized controlled trial in Norway involving 44 physiotherapists.
- The trial included 724 patients with various pain conditions, comparing outcomes for those using the CDSS alongside usual care to those receiving usual care alone, focusing on self-reported improvement measures.
- Results showed no significant difference in overall improvement between the groups, but control group patients reported better functional improvements; researchers noted limitations and suggest more research on AI applications in pain management.
Article Synopsis
- - This study explored adult patients' treatment preferences for shoulder pain in primary care, using a discrete choice experiment where participants compared different treatment options.
- - Three main groups were identified: one that mainly opted out unless treatments were highly effective, another that preferred treatments without injections, and a third group that also preferred to opt out and avoided treatment.
- - The likelihood of joining each group was influenced by past experiences with injections or physiotherapy, indicating that these previous treatments affected their current preferences.