Contact lens induced papillary conjunctivitis with silicone hydrogel lenses.

Purpose: To describe the refitting of a soft lens wearer into a silicone hydrogel lens due to neovascularization. This change, in turn, caused contact lens induced papillary conjunctivitis (CLPC) and a further refitting was necessary.

Methods: The patient was refit into a high Dk surface treated silicone hydrogel with a high modulus value.

Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.

"Early-onset glaucoma" refers to genetically heterogeneous conditions for which glaucoma manifests at age 5-40 years and for which only a small subset is molecularly characterized. We studied the role of MYOC, CYP1B1, and PITX2 in a population (n=60) affected with juvenile or early-onset glaucoma from the greater Toronto area. By a combination of single-strand conformation polymorphism and direct cycle sequencing, MYOC mutations were detected in 8 (13.

Clinical characterization of spherical post-lens debris associated with lotrafilcon high-Dk silicone lenses.

Purpose: Experience with high Dk silicone hydrogel lenses has revealed post-lens debris, which is characterized by the appearance of spherical, translucent particles referred to as "mucin balls." The objectives of this analysis were to characterize the presence of mucin balls, determine whether any ocular characteristic predicts the development of mucin ball debris, and determine whether there is any association between mucin balls and the ocular response to contact lens wear.

Methods: Ninety-two subjects wore lotrafilcon A lenses on an extended wear basis for up to 30 nights and were followed for 6 months.

The genetic aspects of adult-onset glaucoma: a perspective from the Greater Toronto area.

Background: The myocilin gene is the first glaucoma gene to be associated with primary open-angle glaucoma (POAG). The hereditary subset of POAG and the role of the myocilin gene in our population are not clearly defined. Identification of cases of hereditary glaucoma and a better appreciation of the role of the myocilin gene may allow earlier diagnosis of the disease and optimize management of those at risk for glaucoma.