Publications by authors named "D Werling"
Article Synopsis
- Macrophage cellular metabolism during tuberculosis (TB) infection is important because of the changes caused by different species, specifically their effects on macrophage bioenergetics.
- Recent research indicates that TB infection leads to a shift in macrophage metabolism towards aerobic glycolysis, similar to the pro-inflammatory response seen with LPS in M1 macrophages, but there are notable differences in metabolic profiles between mice and humans.
- This study compared the metabolic responses of bovine and human macrophages to TLR ligands, finding that while both species showed similar respiratory profiles, human macrophages had a unique reaction to PPD, enhancing both basal respiration and glycolysis, which could explain varying inflammatory responses in zoonotic diseases.
Article Synopsis
- * A pilot study used Reduced Representation Bisulfite Sequencing to compare methylation patterns in healthy calves versus those with BRD, and healthy calves versus adult dairy cows, revealing significant differences in gene methylation.
- * Findings showed that BRD-affected calves had 964 differentially methylated genes related to immune responses and vascular regulation, highlighting the need for further research to improve breeding for disease resistance and longevity in cattle.
Article Synopsis
- Whole-genome sequencing (WGS) of Korean autism families reveals that autistic females have a higher genetic burden than males, indicating a higher liability threshold for females compared to males across different ancestries.
- The study analyzes data from a large sample of Korean individuals and compares it with European ancestry cohorts, finding that sex differences in genetic burden and autism symptoms vary significantly.
- Results show that while females carry more damaging genetic variants, male siblings of autistic females display more severe social communication issues, highlighting the complexity of autism's genetic factors and the influence of sex on autistic traits.
Coccidiosis, caused by parasites, significantly impacts poultry farm economics and animal welfare. Beyond its direct impact on health, infection disrupts enteric microbial populations leading to dysbiosis and increases vulnerability to secondary diseases such as necrotic enteritis, caused by . The impact of infection or anticoccidial vaccination on host gastrointestinal phenotypes and enteric microbiota remains understudied.
View Article and Find Full Text PDFVariants in cis-regulatory elements link the noncoding genome to human pathology; however, detailed analytic tools for understanding the association between cell-level brain pathology and noncoding variants are lacking. CWAS-Plus, adapted from a Python package for category-wide association testing (CWAS), enhances noncoding variant analysis by integrating both whole-genome sequencing (WGS) and user-provided functional data. With simplified parameter settings and an efficient multiple testing correction method, CWAS-Plus conducts the CWAS workflow 50 times faster than CWAS, making it more accessible and user-friendly for researchers.
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