Publications by authors named "D Weinzapfel"
GABA(A) receptor function was studied in cerebral cortical vesicles prepared from rats after intracerebroventricular microinjections of antisense oligodeoxynucleotides (aODNs) for alpha1, gamma2, beta1, beta2 subunits. GABA(A) receptor alpha1 subunit aODNs decreased alpha1 subunit mRNA by 59+/-10%. Specific [3H]GABA binding was decreased by alpha1 or beta2 subunit aODNs (to 63+/-3% and 64+/-9%, respectively) but not changed by gamma2 subunit aODNs (94+/-5%).
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- A study examined the effects of various drugs (ipsapirone, nefazodone, tiaspirone, BMS-20661, buspirone, and gepirone) on the hypothalamic-pituitary-adrenal (HPA) axis, focusing on their 5-HT1A receptor-binding properties for treating anxiety and mood disorders.
- The drugs increased plasma corticosterone levels in a dose-dependent manner, with BMS-20661 and ipsapirone being the most effective at lower doses.
- Different administration timings affected drug efficacy: BMS-20661 inhibited stress-related corticosterone spikes, while nefazodone reduced HPA activity; dexamethasone significantly suppressed corticosterone levels
Article Synopsis
- The study examined the effects of various 5-HT1A and 5-HT2 agents on HPA axis activity by measuring plasma corticosterone levels.
- It found that these drugs increased corticosterone levels in a dose-dependent fashion, with specific ED50 values for each agent and peak effects occurring between 30 minutes and 1 hour.
- Additionally, in stressful conditions, gepirone and enciprazine elevated corticosterone levels while carvotroline had the opposite effect, and pretreatment with dexamethasone diminished the HPA axis activity induced by the drugs.