Publications by authors named "D Weihs"
Article Synopsis
- Metastasis is responsible for 90% of cancer-related deaths, particularly in triple-negative breast cancer (TNBC), making it essential to understand molecular drivers to find better prognostic markers after chemotherapy.
- Current chemotherapy treatments like doxorubicin and paclitaxel affect tumor cells in various ways, including activating the unfolded protein response (UPR), with GRP78 playing a significant but controversial role in metastasis.
- The study identifies subpopulations of GRP78+ and GRP78- cells in TNBC, demonstrating that while GRP78- cells are more invasive, the combination of both subpopulations may influence overall metastatic potential, offering insights for personalized cancer treatment strategies.
Metastases are the leading cause of cancer-associated deaths. A key process in metastasis is cell invasiveness, which is driven and controlled by cancer cell interactions with their microenvironment. We have previously shown that invasive cancer cells forcefully push into and indent physiological stiffness gels to cell-scale depths, where the percentage of indenting cells and their attained depths provide clinically relevant predictions of tumor invasiveness and the potential metastatic risk.
View Article and Find Full Text PDFCancer cell migration between different body parts is the driving force behind cancer metastasis, which is the main cause of mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in locally stiff, yet flexible tissues. In our previous work, we developed a model for cell geometry evolution during invasion, which we extend here to investigate whether leader and follower (cancer) cells that only interact mechanically can benefit from sequential transmigration through narrow micro-channels and cavities.
View Article and Find Full Text PDFPurpose: The prognosis of microsatellite stable (MSS) versus instable (MSI) tumors is an ongoing matter of debate, with differences in expression of carcinoembryonic antigen (CEA) in these two tumor subsets being inconsistently reported to date. The aim of this study was to investigate CEA expression in the context of clinical parameters in MSS and MSI tumors.
Methods: Clinical, pathological, and biochemical parameters of colon cancer patients who underwent curative surgery were documented in a database and compared between MSS and MSI cases.