Publications by authors named "D Weber-Adrian"
Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused ultrasound (MRIgFUS) to temporarily and locally permeabilize the blood-brain barrier. Vector and promoter selection can provide neuronal expression in the brain, while limiting biodistribution and expression in peripheral organs. To date, the biodistribution of adeno-associated viruses (AAVs) within peripheral organs had not been quantified following intravenous injection and MRIgFUS delivery to the brain.
View Article and Find Full Text PDFPurpose: The use of assisted reproductive technology (ART) has increased in the last 2 decades and continuous surveillance is needed. This systematic review aims to assess the risk of adverse neonatal outcomes (preterm birth [PTB], low birth weight [LBW], small-for-gestationalage [SGA] and large for gestational-age [LGA]), in singleton pregnancies conceived by fresh or frozen embryo transfer (FET) compared to spontaneous conceptions.
Methods: Cohort studies were identified from MEDLINE, Embase, Cochrane Library (January 2019), and manual search.
Article Synopsis
- Gene therapy targeting neurodegenerative disorders can utilize the glial fibrillary acidic protein (GFAP) promoter to boost transgene expression near amyloid-beta plaques associated with Alzheimer's disease.
- The study employed MRI-guided focused ultrasound with microbubbles to increase the blood-brain barrier's permeability, allowing for targeted delivery of viral vectors to specific brain regions in mouse models.
- Results showed that using the GFAP promoter led to stronger transgene expression in areas with amyloid plaques compared to a standard promoter, indicating potential advantages for future therapies aimed at neurological conditions.
Functional Amyloids and their Possible Influence on Alzheimer Disease.
Discoveries (Craiova)
October 2017
Article Synopsis
- Amyloids are significant in both human diseases and naturally occurring processes, showing potential for interaction and mutual influence in their aggregation.
- A specific example includes the interaction between amyloid β peptide (Aβ), linked to Alzheimer’s disease, and somatostatin (SST), which is stored as amyloid before being released during neuronal activity.
- The review explores existing literature on Aβ and SST, their individual biogenesis and interactions, and speculates on their encounters in the brain, emphasizing SST's relevance to Alzheimer's pathobiology while suggesting that interactions among various amyloids could be crucial for understanding dementias and related disorders.
Read the highlighted article 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells' on page 216.
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