Publications by authors named "D Webber"
Article Synopsis
- Environmental enteric dysfunction (EED) is a condition impacting the small intestine, frequently seen in stunted children, characterized by damaged gut barrier and reduced nutrient absorption.
- A study with gnotobiotic mice showed that specific bacterial strains from stunted children can cause inflammation and immune changes similar to those found in EED, impacting gut and brain function.
- The research highlights a strain, Campylobacter concisus, as a potential contributor to gut issues, suggesting that targeting small intestinal microbiota could lead to new treatments for undernutrition across generations.
Article Synopsis
- A randomized controlled trial was conducted in Bangladesh on children aged 12-18 months, comparing a microbiome-directed complementary food (MDCF-2) with a calorically dense standard food, revealing better weight-for-length improvement in those treated with MDCF-2.
- The study also found significant protein and microbiome changes associated with the recovery process, suggesting potential biomarkers for treatment response and the need for further research on MDCF efficacy.
Carbohydrates comprise the largest fraction of most diets and exert a profound impact on health. Components such as simple sugars and starch supply energy, while indigestible components, deemed dietary fiber, reach the colon to provide food for the tens of trillions of microbes that make up the gut microbiota. The interactions between dietary carbohydrates, our gastrointestinal tracts, the gut microbiome and host health are dictated by their structures.
View Article and Find Full Text PDFArticle Synopsis
- * A randomized controlled trial inBangladesh tested a microbiota-directed complementary food (MDCF-2) against a ready-to-use supplementary food (RUSF) in children transitioning from SAM to MAM, finding MDCF-2 led to better weight gain improvements.
- * The study also identified 215 beneficial plasma proteins associated with improved growth and demonstrated changes in the children's gut microbiome, highlighting specific bacterial strains that may help in recovery, suggesting a need for further research on MDCF's effectiveness and potential treatment markers.