Catalyst-Free Photooxidative N-Acylation of Azoles with Aldehydes.

A catalyst-free photochemical N-acylation of azoles with aldehydes has been developed using inexpensive BrCCl3 as the oxidant. This transition-metal- and photocatalyst-free amidation proceeded efficiently with a wide variety of substrates to give the corresponding N-acylazoles, including for the late modification of pharmaceutically active molecules, and on a gram-scale.

The sleep for health study: A randomized clinical trial of the impact of insomnia treatment on glycemia in people with prediabetes.

Background: Insomnia is a modifiable risk factor for type 2 diabetes.

Objective: Describe the methodology for the Sleep for Health study, a randomized clinical trial examining the effectiveness of digital cognitive behavioral therapy for insomnia (dCBT-I) in reducing hyperglycemia in 300 people with both insomnia and prediabetes.

Outcomes: Primary outcome is glucose level 2 h after a 75-g glucose load.

Emissions of HFC-23 do not reflect commitments made under the Kigali Amendment.

HFC-23 (trifluoromethane) is a potent greenhouse gas released to the atmosphere primarily as a by-product of HCFC-22 (chlorodifluoromethane) synthesis. Since 2020, the Kigali Amendment to the Montreal Protocol has required Parties to destroy their HFC-23 emissions to the extent possible. Here, we present updated HFC-23 emissions estimated from atmospheric observations.