Optimum diagnostic pathway and pathologic confirmation rate of early stage lung cancer: Results from the VIOLET randomised controlled trial.

Background: Pathologic confirmation of lung cancer influences treatment selection for suspected early-stage lung cancer. High pre-treatment tissue confirmation rates are recommended. We sought to define management and outcomes of patients undergoing surgery for primary lung cancer in a UK multi-centre clinical trial.

Unsupervised self-organising map classification of Raman spectra from prostate cell lines uncovers substratified prostate cancer disease states.

Prostate cancer is a disease which poses an interesting clinical question: Should it be treated? Only a small subset of prostate cancers are aggressive and require removal and treatment to prevent metastatic spread. However, conventional diagnostics remain challenged to risk-stratify such patients; hence, new methods of approach to biomolecularly sub-classify the disease are needed. Here we use an unsupervised self-organising map approach to analyse live-cell Raman spectroscopy data obtained from prostate cell-lines; our aim is to exemplify this method to sub-stratify, at the single-cell-level, the cancer disease state using high-dimensional datasets with minimal preprocessing.

Impacts of Air Velocity Treatments Under Summer Conditions: Part III-Litter Characteristics, Ammonia Emissions, and Leg Health of Heavy Broilers.

The broiler industry is crucial for rural economies, but it faces challenges in enhancing animal performance and well-being, particularly due to heat stress and ammonia (NH) in grow-out houses. This study investigates the effectiveness of air velocity (AV) treatment in reducing heat stress and NH emissions while also improving litter conditions to enhance animal welfare. Conducted at the North Carolina State University's poultry engineering laboratory, the research used six identical controlled chambers, exposing broilers to High and Low AV treatments from 28 to 61 days across four flocks during the summers of 2017 and 2018.

Trends in Kidney Function and Chronic Kidney Disease after Surgery for Acute Type A Aortic Dissection.

Background: We sought to assess the effect of postoperative renal failure (RF) on outcomes of acute type A aortic dissection (ATAAD) and identify predictors of chronic kidney disease (CKD) following ATAAD.

Methods: This retrospective single-center analysis included all adults with ATAAD from 2011 to 2023. Patients were stratified into RF and no RF groups.