Pharmacokinetics and safety of bictegravir in pregnant and postpartum persons with HIV and their infants.

Background: Limited data exist on bictegravir pharmacokinetics in pregnancy among persons with HIV (PWH) and infant washout.

Setting: Nonrandomized, open-label, multi-center phase-IV prospective study of bictegravir pharmacokinetics and safety in pregnant PWH and their infants.

Methods: Steady-state 24-hour pharmacokinetic sampling of oral bictegravir 50 mg once daily (a component of fixed-dose combination bictegravir/emtricitabine/tenofovir alafenamide) during the 2nd and 3rd trimesters and postpartum was performed.

Bridging the Gap: Advancing Latine Representation in Child and Adolescent Psychiatry Amidst US Demographic Shifts.

The United States is witnessing a demographic transformation, with the Latine population rapidly growing. As the nation's demographics evolve, the underrepresentation of Latine child and adolescent psychiatry (CAP) professionals compared to their proportion in the broader population underscores a pressing gap that requires prompt and focused efforts. This discrepancy is particularly concerning given the documented mental health inequities affecting Latine youth.

Boosting the Performance of Alkaline Anion Exchange Membrane Water Electrolyzer with Vanadium-Doped NiFeO.

Developing efficient, economical, and stable catalysts for the oxygen evolution reaction is pivotal for producing large-scale green hydrogen in the future. Herein, a vanadium-doped nickel-iron oxide supported on nickel foam (V-NiFeO/NF) is introduced, and synthesized via a facile hydrothermal method as a highly efficient electrocatalyst for water electrolysis. X-ray photoelectron and absorption spectroscopies reveal a synergistic interaction between the vanadium dopant and nickel/iron in the host material, which tunes the electronic structure of NiFeO to increase the number of electrochemically active sites.

Outpatient follow-up and future care-seeking for pediatric ambulatory care-sensitive conditions.

Objectives: Outpatient follow-up visits are often recommended for children with ambulatory care-sensitive conditions (ACSCs) who are discharged from emergency departments or urgent care centers (acute care settings). We sought to assess whether attending a follow-up visit within 7 days is associated with seeking initial office-based care rather than acute care during a subsequent ACSC illness. Understanding this association is crucial to guide recommendations for routine short-term follow-up visits in children who seek acute care for these common conditions.