Publications by authors named "D W Sexton"
Objective: The Endoscopic Third Ventriculostomy Success Score (ETVSS) is a useful decision-making heuristic when considering the probability of surgical success, defined traditionally as no repeat cerebrospinal fluid diversion surgery needed within 6 months. Nonetheless, the performance of the logistic regression (LR) model in the original 2009 study was modest, with an area under the receiver operating characteristic curve (AUROC) of 0.68.
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- The number of kidney transplant recipients has significantly increased over the past 20 years due to advancements in medical technology.
- Nephrologists play a crucial role in providing ongoing care for transplant patients, focusing on long-term health management.
- It's essential for nephrologists to have an in-depth understanding of key issues like immunosuppression, potential infections, and factors leading to kidney graft dysfunction.
sp. is a thermally dimorphic genus of fungi known to cause subacute or chronic subcutaneous lesions in humans and animals and is the cause of increasing public health concern due to spread of feline-associated cases. Here, we adapted and evaluated a recently described real-time PCR assay targeting the β-tubulin gene to rapidly detect and differentiate two related species, and .
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- The study aimed to assess whether the COVID-19 pandemic impacted the incidence of pediatric hydrocephalus surgeries, hypothesizing that surgical volumes would remain stable despite the pandemic.
- Data was gathered from ten institutions about hydrocephalus-related surgeries conducted from March 2018 to February 2022, comparing the COVID-19 era to a pre-COVID baseline.
- Results showed no significant overall change in monthly surgeries during the pandemic compared to pre-COVID, but there was a noticeable decline during the initial surge in April 2020, with disparities noted in patient demographics including sex and race.
Article Synopsis
- Cleaved high-molecular-weight kininogen (HKa) serves as a biomarker for the activation of the kallikrein-kinin system (KKS) in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH).
- The study aimed to create an HKa-specific enzyme-linked immunosorbent assay (ELISA) for monitoring KKS activation in the blood of HAE-C1INH patients, utilizing a specific antibody found through phage display.
- Results showed that HKa levels were significantly higher in HAE-C1INH patients during attacks compared to healthy controls, indicating the potential of this ELISA for advancing drug development and understanding related diseases.