Publications by authors named "D W Schafer"
Article Synopsis
- Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
- Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
- New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
[Combination of science, clinic and public health care: DMW 1875-1933].
Dtsch Med Wochenschr
December 2024
Multiple sclerosis (MS) is initially characterized by myelin and axonal damage in central nervous system white matter lesions, but their causal role in synapse loss remains undefined. Gray matter atrophy is also present early in MS, making it unclear if synaptic alterations are driven by white matter demyelinating lesions or primary gray matter damage. Furthermore, whether axonal pathology occurs secondary to or independent of demyelination to drive synaptic changes is not clear.
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- The study analyzes the formation of contrails from ammonia-powered engines compared to traditional jet fuel engines, focusing on thermodynamic processes like supersaturation and ice nucleation.
- It calculates how moisture from exhaust affects atmospheric conditions, determining the potential for contrail visibility based on temperature and humidity changes.
- Findings suggest that ammonia contrails are less dense but can form at lower altitudes and last longer due to higher moisture content, despite not producing soot which typically aids contrail formation.
Nucleic acids are a critical trigger for the innate immune response to infection, wherein pathogen-derived RNA and DNA are sensed by nucleic acid sensing receptors. This subsequently drives the production of type I interferon and other inflammatory cytokines to combat infection. While the system is designed such that these receptors should specifically recognize pathogen-derived nucleic acids, it is now clear that self-derived RNA and DNA can also stimulate these receptors to cause aberrant inflammation and autoimmune disease.
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