Publications by authors named "D W Posthuma De Boer"
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup.
Article Synopsis
- Gaucher disease (GD) is a genetic lysosomal storage disorder caused by a deficiency in the enzyme glucocerebrosidase (GBA1), and its diagnosis typically employs assays that can be compromised by background activity from other enzymes.
- Researchers have developed a selective fluorogenic substrate called 6-O-alkyl-4MU-β-Glc, which effectively targets GBA1 and avoids interference from other enzymes, making it suitable for diagnosing GD.
- Additionally, analyses of spleen samples from GD patients revealed increased levels of acylated and regular glycosyl lipids, highlighting a potential link between plant-derived glycosyl phytosterols and the disease, raising questions about their role in developing conditions like Parkinson's
Unlabelled: BackgroundThe Organisation for Economic Co-operation and Development (OECD) Patient-Reported Indicator Surveys (PaRIS) initiative aims to support countries in improving care for people living with chronic conditions by collecting information on how people experience the quality and performance of primary and (generalist) ambulatory care services. This paper presents the development of the conceptual framework that underpins the rationale for and the instrumentation of the PaRIS survey.
Methods: The guidance of an international expert taskforce and the OECD Health Care Quality Indicators framework (2015) provided initial specifications for the framework.
Background And Objectives: Although physical therapy, in particular exercise therapy, is widely used in nursing home residents with dementia, the literature on this topic is relatively scarce. This systematic review aimed to summarize the literature on the characteristics and effectiveness of exercise interventions supervised by physical therapists in nursing home residents with dementia.
Research Design And Methods: Six electronic databases were systematically searched for relevant studies up to August 17, 2022.