Publications by authors named "D W Peckham"
Background: Whether improvements in gastrointestinal (GI) symptoms observed with Elexacaftor/Tezacaftor/Ivacaftor (ETI) treatment are sustained in the longer-term requires exploration. This study investigated how GI-symptoms change with longer-term ETI use in pancreatic insufficient adults with cystic fibrosis (awCF).
Methods: Participants completed up to three abdominal symptom questionnaires, employing the validated CFAbd-Score.
Background: Piperacillin-tazobactam is used in patients with cystic fibrosis to treat recurrent respiratory infections. Exposure is associated with a high frequency of nonimmediate hypersensitivity.
Objective: To assess the applicability of the lymphocyte transformation test (LTT) for the diagnosis of piperacillin hypersensitivity and the influence of desensitization on piperacillin-specific T-cell responses.
Article Synopsis
- The study focuses on the detection of ASC aggregates, which are important for inflammasome assembly, particularly the NLRP3 inflammasome, after pyroptotic cell death.
- Researchers developed a method using human monocytes, macrophages, and ASC reporter cells to identify ASC/NLRP3-positive events via flow cytometry.
- Results showed increased ASC/NLRP3 specks in the sera of patients with inflammatory conditions, indicating that FACS is a reliable detection method with potential diagnostic uses in autoinflammatory diseases.
Article Synopsis
- Musculoskeletal issues are common among people with cystic fibrosis (CF), but there’s a lack of accurate data on how often these problems occur and their effects.
- A study surveyed 489 adults from UK CF centers, finding that nearly half experienced musculoskeletal symptoms that impacted daily activities, with back and knee pain being especially prevalent.
- The research concluded that while musculoskeletal symptoms are frequent in CF, they are often not caused by inflammatory arthritis, indicating a need for better understanding and management of these issues.