Publications by authors named "D W Patton"
Purpose: The NCI-MATCH trial assigned patients with solid tumors, lymphomas, or multiple myeloma to targeted therapies on the basis of identified genetic alterations from tumor biopsies. In preclinical models, ()-inactivated tumors display sensitivity to focal adhesion kinase (FAK) inhibition. The EAY131-U subprotocol evaluated the efficacy of defactinib, a FAK inhibitor, in patients with -altered tumors.
View Article and Find Full Text PDFPurpose: Mismatch repair deficient (dMMR) tumors have demonstrated favorable responses to immune checkpoint inhibition targeting PD-1. However, more in-depth identification of predictors of response could further refine patient selection for immunotherapy treatment.
Experimental Design: We undertook integrated evaluation performed on samples collected from 28 of 42 patients enrolled on the NCI-MATCH arm Z1D trial that evaluated PD-1 inhibition treatment with nivolumab in patients with non-colorectal dMMR tumors.
Purpose: The NCI-MATCH study is a tumor-agnostic platform trial enrolling patients to targeted therapies on the basis of genomic alterations. Subprotocol V investigated sunitinib in patients with tumors harboring - mutations.
Methods: EAY131-V, is an open-label, single-arm, phase II study.
Dressings and topical agents for preventing pressure ulcers.
Cochrane Database Syst Rev
December 2024
Article Synopsis
- Pressure ulcers are serious injuries caused by prolonged pressure on the skin, especially over bony areas, and they pose significant challenges in healing and treatment costs.
- This review evaluates the effectiveness of various dressings and topical agents in preventing pressure ulcers for individuals at risk, without any existing ulcers, across different healthcare settings.
- The update includes 51 trials with over 13,000 participants, showing that certain dressings, like silicone foam, can significantly reduce the incidence of pressure ulcers compared to no dressing at all.
Article Synopsis
- Polyacrylonitrile (PAN) is crucial for producing carbon fiber, with 90% of the market depending on PAN-based polymers.
- Traditional PAN synthesis has drawbacks, such as broad molecular weight distributions and the use of toxic solvents, while controlled radical polymerization methods struggle with low efficiency and inadequate molecular weights.
- The study introduces an innovative aqueous photoiniferter (aqPI) polymerization technique that achieves high monomer conversion and superior PAN characteristics, enhancing control over properties vital for improved carbon fiber production.