Publications by authors named "D W Ownby"
The relationship between the early life gastrointestinal microbiome and childhood nocturnal cough.
J Allergy Clin Immunol
January 2025
Background: Nocturnal cough affects approximately 1 in 3 children, can negatively impact child health, and is often attributable to asthma. The association of the gut microbiome with nocturnal cough has not been investigated.
Objective: To investigate the association between early-life gut microbiome composition and nocturnal cough overall and in the context of asthma.
Comparison of Race-neutral Versus Race-specific Spirometry Equations for Evaluation of Child Asthma.
Am J Respir Crit Care Med
December 2024
Rationale: Race-based estimates of pulmonary function in children could influence the evaluation of asthma in children from racial and ethnic minoritized backgrounds.
Objectives: To determine if race-neutral (GLI-Global) versus race-specific (GLI-Race-Specific) reference equations differentially impact spirometry evaluation of childhood asthma.
Methods: The analysis included 8,719 children aged 5 to <12 years from 27 cohorts across the United States grouped by parent-reported race and ethnicity.
Article Synopsis
- * Researchers assessed data from 4,849 children, finding that those living in areas classified as high-risk (grade D) had a significantly higher incidence of asthma, with 79% of this increased risk linked to low-income households.
- * The findings suggest that structural racism, as exemplified by redlining, continues to influence health outcomes today, highlighting the need for policies aimed at addressing these long-standing disparities for healthier communities.
Importance: Exposure to outdoor air pollution contributes to childhood asthma development, but many studies lack the geographic, racial and ethnic, and socioeconomic diversity to evaluate susceptibility by individual-level and community-level contextual factors.
Objective: To examine early life exposure to fine particulate matter (PM2.5) and nitrogen oxide (NO2) air pollution and asthma risk by early and middle childhood, and whether individual and community-level characteristics modify associations between air pollution exposure and asthma.