Mapping the composite nature of clay matrix in mudstones: integrated micromechanics profiling by high-throughput nanoindentation and data analysis.

Unlabelled: Mudstones and shales serve as natural barrier rocks in various geoenergy applications. Although many studies have investigated their mechanical properties, characterizing these parameters at the microscale remains challenging due to their fine-grained nature and susceptibility to microstructural damage introduced during sample preparation. This study aims to investigate the micromechanical properties of clay matrix composite in mudstones by combining high-speed nanoindentation mapping and machine learning data analysis.

Pralsetinib in patients with RET fusion-positive non-small-cell lung cancer: A plain language summary of the ARROW study.

What Is This Summary About?: This is a summary of a research study called ARROW, which tested a medicine called pralsetinib in patients with non-small cell lung cancer (NSCLC), thyroid cancer, and other advanced solid tumours caused by a change in a gene called . For the purposes of this summary, only patients with NSCLC with a change in called fusion ( fusion+) are highlighted.

What Were The Results?: In total, 281 patients with fusion+ NSCLC had taken part in this study across the USA, Europe, and Asia.

Axenic Long-Term Cultivation of .

, a fungus causing severe pneumonia (PCP) in humans, has long been described as non-culturable. Only isolated short-term experiments with and a small number of experiments involving animal-derived species have been published to date. However, culture conditions may differ significantly from those of animal-derived , as there are major genotypic and phenotypic differences between them.