Publications by authors named "D W Leonard"
Objectives: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.
Methods: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were available (n = 7742).
Objective: To determine the associations between muscle-strengthening activity (MSA) and cognitive function among middle-aged and older adults.
Methods: This cross-sectional study included 2973 participants aged ≥55 in the Cooper Center Longitudinal Study. Participants self-reported leisure-time physical activity.
Article Synopsis
- The LUX-ZEPLIN (LZ) experiment is a significant scientific study using a dual-phase xenon chamber located underground in South Dakota to search for dark matter interactions.
- The study extends existing theories to include relativistic effects, providing new constraints on the interactions between weakly interacting massive particles and nucleons based on their electric and magnetic dipole moments.
- Results include 90% confidence level limits on the coupling strength of five different interactions, analyzed over a specific energy range, which advances our understanding in particle physics beyond previous nonrelativistic effective field theories.
The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes. Insulin doses must be adjusted to ensure that blood glucose values are within the normal range, but matching insulin doses to fluctuating glucose levels is difficult because even a slightly higher insulin dose than needed can lead to a hypoglycaemic incidence, which can be anything from uncomfortable to life-threatening. It has therefore been a long-standing goal to engineer a glucose-sensitive insulin that can auto-adjust its bioactivity in a reversible manner according to ambient glucose levels to ultimately achieve better glycaemic control while lowering the risk of hypoglycaemia.
View Article and Find Full Text PDFPurpose: Cardiorespiratory fitness (CRF) declines with age, and greater declines increase the risk for adverse health outcomes. Understanding factors that attenuate age-related decreases in CRF can help extend healthy life. We sought to determine the longitudinal associations of aerobic physical activity, muscle-strengthening activity (MSA), and adiposity with CRF.
View Article and Find Full Text PDF