Loss of chaperone-mediated autophagy does not alter age-related bone loss in male mice.

Chaperone-mediated autophagy (CMA) is a lysosome-dependent degradation pathway that eliminates proteins that are damaged, partially unfolded, or targeted for selective proteome remodeling. CMA contributes to several cellular processes, including stress response and proteostasis. Age-associated increase in cellular stressors and decrease in CMA contribute to pathologies associated with aging in various tissues.

Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass.

Chaperone-mediated autophagy (CMA) is a protein degradation pathway that eliminates soluble cytoplasmic proteins that are damaged, incorrectly folded, or targeted for selective proteome remodeling. However, the role of CMA in skeletal homeostasis under physiological and pathophysiological conditions is unknown. To address the role of CMA for skeletal homeostasis, we deleted an essential component of the CMA process, namely Lamp2a, from the mouse genome.

Stem design and dislocation after revision total hip arthroplasty: clinical results and computer modeling.

The effect of the size and shape of the neck and the taper of the femoral stem on dislocation rate after revision total hip arthroplasty was examined. Design I had a large (14/16), long taper with a circular neck cross-section; a fixed 42-mm offset; and a neck that was anteverted relative to the stem. Design II was characterized by a smaller (12/14), shorter taper; a trapezoidal neck cross-section; a progressive (40-50 mm) offset; and no neck anteversion relative to the stem.

The natural history of intracranial venous angiomas.

Cerebral venous angiomas are congenital anomalies of the intracranial venous drainage. Many believe that they are associated with a high risk of hemorrhage and neurological dysfunction, but newer neurodiagnostic imaging techniques are showing not only that they are more common than previously known but also that many have no associated symptoms. In this retrospective study, the natural history of venous angiomas was examined in 100 patients (48 males and 52 females) with radiographically identifiable lesions treated over a 14-year period.