Publications by authors named "D W Hunt"
Article Synopsis
- The TAOK proteins are important kinases involved in various cellular functions and are linked to neurodevelopmental disorders (NDDs) like those caused by TAOK1 and TAOK2 variants.
- A study analyzed clinical and genetic data from individuals with these variants, revealing that TAOK1 variants lead to significant neurodevelopmental issues and some novel characteristics, while TAOK2 variants are tied to neurodevelopmental abnormalities, autism, and obesity.
- This research expands the understanding of these disorders by presenting the largest cohort of individuals with TAOK1-NDD and identifying new variants and phenotypes associated with both TAOK1 and TAOK2.
Article Synopsis
- The LUX-ZEPLIN (LZ) experiment is a significant scientific study using a dual-phase xenon chamber located underground in South Dakota to search for dark matter interactions.
- The study extends existing theories to include relativistic effects, providing new constraints on the interactions between weakly interacting massive particles and nucleons based on their electric and magnetic dipole moments.
- Results include 90% confidence level limits on the coupling strength of five different interactions, analyzed over a specific energy range, which advances our understanding in particle physics beyond previous nonrelativistic effective field theories.
Article Synopsis
- A study aimed to explore the links between running biomechanics and the musculotendinous characteristics of adolescent runners, as well as changes in these properties over a period of six months.
- Thirty-three adolescents participated, undergoing ultrasound evaluations and wearable sensor assessments to analyze different muscle and tendon attributes and running mechanics.
- Results showed that specific biomechanics, like pronation and contact time, significantly predicted changes in muscle and tendon thickness, highlighting potential influences of running mechanics on physical development in young athletes.
Tractometry of diffusion-weighted magnetic resonance imaging (dMRI) non-invasively quantifies tissue properties of brain connections. It is widely used in aging studies but could be less reliable in aging brains due to increased white matter free water. We demonstrate that computational free water elimination (FWE) increases reliability and accuracy of tractometry in a large (n = 339) cohort of older adults (66 - 103 y.
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- * An international group is collaborating to tackle regulatory challenges related to microneedles combined with pharmaceuticals for skin application, guided by Quality by Design principles.
- * The resulting 'White Paper' highlights key dosage form classifications, potential critical quality attributes, and aims to create a foundation for regulatory guidance that will help bring safe and effective microneedle products to market faster.