Publications by authors named "D W Helbig"
Post-mitotic, non-proliferative dermal fibroblasts have crucial functions in maintenance and restoration of tissue homeostasis. They are involved in essential processes such as wound healing, pigmentation and hair growth, but also tumor development and aging-associated diseases. These processes are energetically highly demanding and error prone when mitochondrial damage occurs.
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- Pleomorphic dermal sarcomas (PDS) are rare skin tumors linked to UV exposure, and their diagnosis and treatment options are limited.
- The study involved analyzing various skin samples using mass spectrometry and focused on understanding the cell origins and protein profiles of PDS compared to other skin cancers like malignant melanomas and cutaneous squamous cell carcinomas.
- Key findings include the identification of fibroblasts as major contributors to tumor purity, distinct receptor/ligand interaction pathways in different cancer types, and specific markers like MAP1B that could help differentiate PDS from other tumors.
Article Synopsis
- * These tumors can be aggressive, often recurring and metastasizing, especially periocular ones (up to 15%), while extraocular cases have a lower metastasis rate (up to 2%).
- * The main treatment is complete micrographically controlled surgery, with additional options like radiotherapy, while advanced cases may require individualized treatment plans from a tumor board due to a lack of standard therapies.
Background: In advanced neuroendocrine tumors (NET), antiproliferative treatment options beyond somatostatin analogs remain limited. Temozolomide (TMZ) has shown efficacy in NET alone or combined with other drugs.
Materials And Methods: SONNET (NCT02231762) was an open, multicenter, prospective, phase II study to evaluate lanreotide autogel 120 mg (LAN) plus TMZ in patients with progressive advanced/metastatic grade 1/2 gastroenteropancreatic (GEP) NET or of unknown primary.