Publications by authors named "D W H Wong"
Objective: Evaluate efficacy of cognitive behavioural therapy for sleep and fatigue adapted for brain injury relative to health education control in alleviating sleep disturbance and fatigue after acquired brain injury.
Design: Parallel groups randomized controlled trial.
Subjects: 126 community dwelling adults with stroke or traumatic brain injury.
Article Synopsis
- Accurate diagnosis of Alzheimer's disease and vascular dementia is vital for timely treatment and better patient outcomes; this study focused on plasma and retinal biomarkers for differentiation among cognitive impairment groups.
- The study involved 509 participants aged 50 and older, categorized into groups based on cognitive function using clinical assessments, neuropsychological tests, and MRI scans.
- The findings revealed that both retinal layer thickness and plasma biomarker levels varied significantly across cognitive impairment levels, with decreases seen in retinal thickness and increases in plasma biomarkers from normal cognition to dementia.
Lateral gene transfer (LGT), also known as horizontal gene transfer, facilitates genomic diversification in microbial populations. While previous work has surveyed LGT in human-associated microbial isolate genomes, the landscape of LGT arising in personal microbiomes is not well understood, as there are no widely adopted methods to characterize LGT from complex communities. Here we developed, benchmarked and validated a computational algorithm (WAAFLE or Workflow to Annotate Assemblies and Find LGT Events) to profile LGT from assembled metagenomes.
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