Publications by authors named "D W Grupe"

Unlabelled: Mediation analysis has emerged as a versatile tool for answering mechanistic questions in microbiome research because it provides a statistical framework for attributing treatment effects to alternative causal pathways. Using a series of linked regressions, this analysis quantifies how complementary data relate to one another and respond to treatments. Despite these advances, existing software's rigid assumptions often result in users viewing mediation analysis as a black box.

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Mediation analysis has emerged as a versatile tool for answering mechanistic questions in microbiome research because it provides a statistical framework for attributing treatment effects to alternative causal pathways. Using a series of linked regressions, this analysis quantifies how complementary data relate to one another and respond to treatments. Despite these advances, existing software's rigid assumptions often result in users viewing mediation analysis as a black box.

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Repeatedly capturing national headlines, excessive law enforcement officer (LEO) use of force in critical incident encounters is one of the most divisive human rights issues in the United States. Valid and reliable measures of potential precursors to LEO excessive use of force, such as aggression, are needed. The Buss-Perry Aggression Questionnaire-short form (BPAQ-SF) is a validated measure of aggression across various populations; however, evaluation of this easily administered measure in high-stress, frontline populations such as LEOs is limited.

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Article Synopsis
  • The study explores the lesser-known role of the cerebellum in PTSD by analyzing cerebellar volume differences in a large sample of 4,215 adults, with 1,642 diagnosed with PTSD and 2,573 as healthy controls.
  • Using advanced deep-learning techniques, researchers assessed the total cerebellum volume and 28 subregions, revealing significant reductions in both gray and white matter in individuals with PTSD, especially in specific posterior lobe and vermis areas.
  • The results suggest that changes in cerebellar structure are linked to cognitive and emotional dysfunctions in PTSD, highlighting the cerebellum's importance beyond its traditional role in motor control.
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