Publications by authors named "D W Franklin"
Unlabelled: Many bacteria metabolize ethanolamine as a nutrient source through cytoplasmic organelles named bacterial microcompartments (BMCs). Here we investigated the molecular assembly, regulation, and function of BMCs in a Gram-negative oral pathobiont that is associated with adverse pregnancy outcomes. The genome harbors a conserved ethanolamine utilization () locus with 21 genes that encode several putative BMC shell proteins and a two-component signal transduction system (TCS), in addition to the enzymes for ethanolamine transport and catabolism.
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- The study investigates how different shielding strategies affect false positive rates in a neutron detection system for Neutron Capture Enhanced Particle Therapy (NCEPT).
- A Monte Carlo model was created to simulate the effects of neutron detection and various shielding configurations on a specific phantom setup.
- Results indicate that while shielding the detector crystal can worsen detection accuracy, adding a thin layer of GdO shield can enhance detection selectivity if boron is present in the detector's printed circuit boards.
It is imperative in a forensic investigation to determine the identity of an unidentified corpse, for which a crucial starting point is to establish population affinity as part of the biological profile supplied by the forensic anthropologist. The present study investigates the feasibility of using multidetector computed tomography (MDCT) images to quantify craniometric variation between Japanese and Malay populations relative to the estimation of population affinity in a forensic context. The Japanese and Malay samples comprise MDCT scans of 252 (122 female; 130 male) and 182 (84 female; 98 male) adult individuals, respectively.
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- Cranial sex estimation traditionally relies on visual assessments by forensic anthropologists, which can be biased and less accurate for diverse populations.
- This study investigates a deep learning (DL) framework to improve sex estimation accuracy using 200 CT scans of Indonesian individuals, finding that the top DL model achieved 97% accuracy, significantly higher than the human observer's 82%.
- The results suggest that DL models can effectively analyze cranial traits while considering overall size and shape, offering a valuable tool to enhance the reliability of sex estimation in forensic anthropology.
Article Synopsis
- - The study aimed to create a refined method for harmonizing cognitive data from various large-scale studies involving people with HIV (PWH), addressing the inconsistencies in cognitive test assessments across different studies.
- - A new harmonization technique was developed using a second-order factor model, which helped overcome challenges posed by the absence of common cognitive tests, ensuring reliable comparison across studies like WIHS, MACS, and others.
- - The results showed that the harmonized cognitive scores were consistent across diverse demographics and accurately reflected variations due to factors like age and education while maintaining the integrity of participants' cognitive development over time.