Continuous Instrument Tracking in a Cerebral Corticectomy Ex Vivo Calf Brain Simulation Model: Face and Content Validation.

Background And Objectives: Subpial corticectomy involving complete lesion resection while preserving pial membranes and avoiding injury to adjacent normal tissues is an essential bimanual task necessary for neurosurgical trainees to master. We sought to develop an ex vivo calf brain corticectomy simulation model with continuous assessment of surgical instrument movement during the simulation. A case series study of skilled participants was performed to assess face and content validity to gain insights into the utility of this training platform, along with determining if skilled and less skilled participants had statistical differences in validity assessment.

Damage Control Surgery in the Era of Globalization of Health Care - Military and International Outcomes: A SystematicReview.

Introduction: Damage Control Surgery (DCS) is a surgical technique used to manage critically ill and injured patients. This study examines the most recent 10-y outcomes related to DCS, with the secondary goal of scrutinizing the outcomes after DCS across surgical theaters.

Methods: Studies published between 2012 and 2021 that described adult patients undergoing Abdominal DCS after traumatic injury were included.

Firsts in their field: the perceptions of women who have led the way.

The role women play in sport has been the subject of considerable discussion and research since the nineteen seventies. Much of this research has been descriptive or focused on the barriers, women face in advancing into a leadership role in a sporting organization. In an attempt to enrich the picture, women role models who occupy or have occupied leadership roles in sporting organizations were identified to gain their perspective, in their own words, on the challenges and requirements needed to be successful.

Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.

Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention of malaria through human studies with DSM265, but currently no drugs against this target are in clinical use. We used structure-based computational tools including free energy perturbation (FEP+) to discover highly ligand efficient, potent, and selective pyrazole-based DHODH inhibitors through a scaffold hop from a pyrrole-based series.

Ecological Dynamics as an Accurate and Parsimonious Contributor to Applied Practice: A Critical Appraisal.

With sport coaches adopting and working toward increasingly evidence-grounded approaches to practice, skill acquisition has appropriately become a critical area for consideration. As part of this growing interest in skill acquisition, the ecological dynamics approach has garnered attention amongst scholars and practitioners with myriad media (e.g.