Publications by authors named "D Vnuk"
Posterolateral spinal fusion (PLF) is a procedure used for the treatment of degenerative spine disease. In this study we evaluated Osteogrow-C, a novel osteoinductive device comprised of recombinant human Bone morphogenetic protein 6 (rhBMP6) dispersed in autologous blood coagulum with synthetic ceramic particles, in the sheep PLF model. Osteogrow-C implants containing 74-420 or 1000-1700 µm ceramic particles (TCP/HA 80/20) were implanted between L4-L5 transverse processes in sheep (Ovis Aries, Merinolaandschaf breed).
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- The study assesses the stability of canine calprotectin (cCP) in serum stored at -80°C, as well as the accuracy of the measurement method used.
- Blood samples from 22 dogs with different medical conditions were analyzed at three points: 4 hours post-separation (T0), and after 8 weeks (T1) and 16 weeks (T2) of freezing.
- Results showed that cCP concentrations increased significantly after long-term storage, indicating that cCP is not stable for 16 weeks at low temperatures, and the method used had some level of imprecision.
This study aimed to evaluate if exercise-induced acute phase response (APR) occurs in endurance horses in response to the race. The study included 23 horses competing in an endurance competition with a successfully passed clinical examination before the race. Blood samples were collected before the start and within 30 min after the end of the race.
View Article and Find Full Text PDFTo date, no single approach to the treatment of osteochondral defects has resulted in satisfactory long-term outcomes, especially in a young and active human population. Emerging innovative tissue engineering strategies, including the use of composite scaffolds, novel cell sources and bioreactors, have shown promising results. However, these techniques need to be validated in translational animal models before they can be implemented in clinical practice.
View Article and Find Full Text PDFBackground: Bipolar or "kissing" cartilage lesions formed on 2 opposite articular surfaces of the knee joint are commonly listed as exclusion criteria for advanced cartilage therapies.
Purpose: To test, in a pilot large-animal study, whether autologous nasal chondrocyte (NC)-based tissue engineering, recently introduced for the treatment of focal cartilage injuries, could provide a solution for challenging kissing lesions.
Study Design: Controlled laboratory study.