Publications by authors named "D Vilchez"
Programmed cell death occurring during plant development (dPCD) is a fundamental process integral for plant growth and reproduction. Here, we investigate the connection between developmentally controlled PCD and fungal accommodation in roots, focusing on the root cap-specific transcription factor ANAC033/SOMBRERO (SMB) and the senescence-associated nuclease BFN1. Mutations of both dPCD regulators increase colonization by the beneficial fungus , primarily in the differentiation zone.
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- Scientists found that a bad version of a gene called FUS causes some really serious types of ALS, a disease that affects muscles and movement.
- The FUS gene gets too tangled with another protein called H1.2, which can make the disease worse, but if scientists lower the levels of H1.2 or stop a process called PARylation, it can help reduce the problems caused by FUS.
- In tiny worms called C. elegans, cutting down on H1.2 and a similar protein helped stop the FUS problems, showing us that learning about these relations can help us find treatments for ALS.
Article Synopsis
- PolyQ diseases are serious brain disorders caused by a repeated section of DNA, and they currently have no good treatments.
- Researchers tested many drugs and found that clofazimine, a medication used for leprosy, can help reduce the toxicity caused by a harmful protein related to Huntington's disease.
- The study shows that clofazimine works by improving cell energy production and may help treat polyQ diseases in the future.
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and manipulating ubiquitin (Ub)-dependent host processes during infection. The studies discussed here highlight the importance of DUB host-pathogen research and underscore the therapeutic potential of inhibiting pathogen-specific DUB activity to prevent infectious diseases.
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