[Study of the bactericidal activity of pristinamycin ].

In vitro, the bacteriostatic activity of pristinamycin varies according to the relative proportion of its two components, P I and P II, following a bell-shaped curve reflecting their synergistic effect. In vivo, the pharmacological profile of both components could be different and their synergistic bacteriostatic effect may therefore vary. This led us to study the bactericidal activity of different concentrations of the two components.

Secnidazole. A 5-nitroimidazole derivative with a long half-life.

The therapeutic activity of a single 2 g dose of secnidazole was studied in patients with urogenital trichomoniasis. In 140 patients, 97% were cured and the drug was well tolerated. In the laboratory, tests on sensitivity were made and the minimal inhibitory concentration (MIC) and the minimal trichomonacidal concentration (MTC) were determined on cultures that had recently been isolated at the clinic, and the pharmacokinetic properties of secnidazole in man were compared with those of tinidazole.

[Experimental pyelonephritis in rats: value in the comparison of antibiotics (author's transl)].

The author discusses the conditions which an experimental pyelonephritis must fulfill to provide therapeutic results which will allow the assessment of new therapeutic agents. He subjects the chosen model to the therapeutic effect of four antibiotics and three antimicrobial drugs. A numeric value is given to the bacteriuria recession slope observed during the experiment.