[Beta-adrenergic receptors and cAMP production in the lymphocytes of patients with differentiated carcinoma of the thyroid gland during hypothyroidism and euthyroidism].

Beta-adrenergic receptors and production of cyclic adenosine monophosphate (cAMP) was investigated in peripheral lymphocytes of patients with differentiated thyroid carcinoma in hypothyroidism and euthyroidism, following therapy with 131I and suppression with thyroid hormones. After 131I therapy of patients with differentiated thyroid carcinoma and suppression by means of thyroid hormones, when the patients became euthyroid, the authors found a significantly lower maximal binding capacity Bmax on lymphocytes, as compared with the same patients before radiotherapy when the patients were hypothyroid. The basic cAMP content in patients with euthyroidism was higher, as compared with hypothyroid patients, the difference being at the borderline of significance (p less than 0.