Publications by authors named "D Viarisio"
Here, we demonstrate that the direct binding of p53 on the IL-18 promoter region regulates its gene expression. However, the presence of E6 and E7 from human papillomavirus type 38 impairs this mechanism via a new inhibitory complex formed by DNA methyltransferase 1 (DNMT1)/PKR/ΔNp73α, which binds to the region formerly occupied by p53 in primary keratinocytes.
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- The study aims to improve early detection of HPV-driven oropharyngeal cancer (HPV-OPC) by investigating antibodies against HPV16 early proteins, which may indicate cancer risk years before diagnosis.
- Researchers analyzed serum samples from participants in the Hamburg City Health Study, identifying individuals positive for HPV16 E6 and other early proteins, and those at high risk were subjected to regular follow-up examinations.
- In total, 35 participants were HPV16 E6 seropositive, with three being diagnosed with stage I HPV-OPC after follow-up, highlighting the potential of early protein serology in cancer screening.
Tumor suppressors can exert pro-proliferation functions in specific contexts. In the beta human papillomavirus type 38 (HPV38) experimental model, the viral proteins E6 and E7 promote accumulation of a wild-type (WT) p53 form in human keratinocytes (HKs), promoting cellular proliferation. Inactivation of p53 by different means strongly decreases the proliferation of HPV38 E6/E7 HKs.
View Article and Find Full Text PDFThe beta human papillomaviruses (HPVs) are subdivided into 5 species (beta-1 to beta-5), and they were first identified in the skin. However, the beta-3 species appears to be more highly represented in the mucosal epithelia than in the skin. Functional studies have also highlighted that beta-3 HPV49 shares some functional similarities with mucosal high-risk (HR) HPV16.
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