Publications by authors named "D Verzola"
Adiponectin removal by the human kidney: A preliminary study.
Nutr Metab Cardiovasc Dis
November 2024
Background And Aims: The adipocyte-derived adiponectin (APN) has potent insulin-sensitizing and anti-inflammatory properties. The adipose tissue is known to be the main source for APN in the circulation, but sites and mechanisms which remove APN from blood are still unknown in humans.
Methods And Results: We reviewed APN data obtained in previous studies in which the inter-organ exchange of amino acids and cytokines was measured in our laboratory.
The retinal pigment epithelium (RPE) contributes to retinal homeostasis, and its metabolic dysfunction is implied in the development of retinal degenerative disease. The isoform M2 of pyruvate kinase (PKM2) is a key factor in cell metabolism, and its function may be affected by insulin-like growth factor 1 (IGF-1). This study aims to investigate the effect of IGF-1 on PKM2 modulation of RPE cells and whether co-treatment with klotho may preserve it.
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- * In this study, human kidney cells exposed to both polyethylene microplastics and BPA showed decreased cell viability and increased pro-oxidant and pro-inflammatory responses compared to those exposed to either substance alone.
- * Additionally, the research found that exposure reduced levels of heat shock protein (HSP90) while increasing aryl hydrocarbon receptor (AHR) expression, highlighting the need for further investigation into how these pollutants interact and affect kidney health.
Background: Chronic kidney disease (CKD) is a progressive systemic condition characterized by numerous complications. Among these, alterations in skeletal muscle physiology, such as sarcopenia, are particularly significant, as they are associated with poor outcomes and reduced quality of life.
Summary: Various interventions, including pharmacological approaches and lifestyle modifications have been investigated to slow CKD progression and prevent or treat its complications.