Publications by authors named "D Venne"
Purpose: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.
Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.
Background: Carbapenem-resistant Enterobacterales are among the most serious antimicrobial resistance (AMR) threats. Emerging resistance to polymyxins raises the specter of untreatable infections. These resistant organisms have spread globally but, as indicated in WHO reports, the surveillance needed to identify and track them is insufficient, particularly in less resourced countries.
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- Pediatric patients with high-grade gliomas have a poor prognosis, and the relationship between the extent of tumor resection and survival rates is not well understood.
- The study aims to determine if complete tumor removal (gross total resection, or GTR) leads to better survival outcomes after one and two years compared to partial removal (subtotal resection, or STR) and simple biopsy in children with these tumors.
- Analysis of 37 studies involving 1,387 patients indicates that GTR is linked to significantly lower mortality rates compared to STR at both one year and two years post-surgery, suggesting that achieving GTR may improve survival outcomes for pediatric high-grade glioma patients.
Objective: In nonambulatory children with predominantly spastic cerebral palsy (CP), the authors compared care needs, symptom burden, and complications after surgical treatment with either intrathecal baclofen (ITB) pump insertion or selective dorsal rhizotomy (SDR). The patients were treated at two Canadian centers with variability in practice pertaining to these surgical options.
Methods: The authors performed a retrospective analysis of nonambulatory children with predominantly spastic quadriplegic or diplegic CP who underwent treatment with ITB or SDR.