Publications by authors named "D Vata"
Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies.
View Article and Find Full Text PDFInfectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020-2022 in the largest emergency hospital in NE Romania.
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- Autoimmune bullous diseases (ABDs) are rare skin conditions characterized by autoantibodies affecting the skin, posing challenges for dermatologists, especially in Romania where there is limited data on their prevalence.
- A study from 2015 to 2019 analyzed 225 patients in northeastern Romania, finding pemphigus to be the most common ABD with an incidence of 8.16 per million, followed by bullous pemphigoid and dermatitis herpetiformis.
- The findings indicated that pemphigus vulgaris occurs more frequently in this region compared to Western Europe, potentially due to unique geographical and genetic factors affecting the local population.
Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity.
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- Diabetes mellitus (DM) is a significant global health issue, affecting over 500 million people and often leading to various skin complications in 30-70% of patients.
- A study involving 103 hospitalized diabetes patients from January 2018 to December 2022 aimed to identify the most common skin manifestations associated with diabetes.
- The findings revealed that diabetic foot (20%), bacterial infections (35%), and dry skin (45%) were the most prevalent skin issues, underscoring the need for early recognition and treatment of these manifestations, which can sometimes appear before a diabetes diagnosis.