Publications by authors named "D Vargo"
Article Synopsis
- Vadadustat is being studied as an oral alternative to injectable treatments for anemia in patients on peritoneal dialysis, showing comparable safety and efficacy to darbepoetin alfa in clinical trials.
- A post hoc analysis of the INNO2VATE trials indicated that for patients on peritoneal dialysis, the rates of major cardiovascular events and changes in hemoglobin levels were similar for both treatments.
- Adverse events were reported less frequently in the vadadustat group compared to the darbepoetin alfa group, suggesting a potentially safer profile for vadadustat in this population.
Background: Pressure injuries are associated with skin temperature changes, but little is known about skin temperature characteristics of the Kennedy Lesion (KL).
Purpose: The purpose of this study was to describe early skin temperature changes in KLs using long-wave infrared thermography.
Methods: KLs were identified from chart review in 10 ICU patients.
Article Synopsis
- - Anemia is common in chronic kidney disease (CKD) and affects patients' quality of life, but current treatments like erythropoiesis-stimulating agents require ongoing injections, which can be inconvenient and have safety concerns related to cardiovascular risks.
- - The study analyzed the safety of vadadustat, a new oral treatment for CKD-related anemia, by pooling data from four clinical trials involving over 7,300 patients.
- - Results showed that vadadustat had comparable rates of treatment-emergent adverse events, serious adverse events, and fatal events to darbepoetin alfa, the standard injectable treatment, indicating it may be a safe alternative for managing anemia in CKD patients.
Article Synopsis
- * A clinical trial showed that vadadustat, a new treatment, was as effective as darbepoetin alfa in raising and maintaining hemoglobin levels in CKD patients, while also increasing EPO levels and circulating red blood cells.
- * Vadadustat improved iron availability for erythroid cells and altered iron markers in the blood, suggesting it may help enhance red blood cell production more effectively than darbepoetin alfa.
Objective: Value is defined as health outcomes important to patients relative to cost of achieving those outcomes: Value = Quality/Cost. For inguinal hernia repair, Level 1 evidence shows no differences in long-term functional status or recurrence rates when comparing surgical approaches. Differences in value reside within differences in cost.
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