Publications by authors named "D Vangala"
Article Synopsis
- Systemic sclerosis (SSc) is a serious autoimmune disease with limited treatment options, and high-dose chemotherapy combined with autologous stem cell transplantation (HD-ASCT) has shown effectiveness, though it comes with substantial risks.
- A study analyzed 32 SSc patients who underwent HD-ASCT between 2000 and 2020, focusing on their survival rates, treatment-related mortality (TRM), and factors influencing outcomes.
- The results indicated a median overall survival of 81 months, with 77% responding positively to treatment within a year, though TRM remains a significant issue, highlighting the importance of identifying high-risk patients and considering individual prognostic factors to potentially improve outcomes.
Pancreatic carcinoma lacks effective therapeutic strategies resulting in poor prognosis. Transcriptional dysregulation due to alterations in KRAS and MYC affects initiation, development, and survival of this tumor type. Using patient-derived xenografts of KRAS- and MYC-driven pancreatic carcinoma, we show that coinhibition of topoisomerase 1 (TOP1) and bromodomain-containing protein 4 (BRD4) synergistically induces tumor regression by targeting promoter pause release.
View Article and Find Full Text PDFAlthough approximately half of all metastatic colorectal cancers (mCRCs) harbour mutations in KRAS or NRAS, hardly any progress has been made regarding targeted treatment for this group over the last few years. Here, we investigated the efficacy of vertical inhibition of the RAS-pathway by targeting epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase kinase (MEK) in patient-derived xenograft (PDX) tumours with primary KRAS mutation. In total, 19 different PDX models comprising 127 tumours were tested.
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