Publications by authors named "D V Weinberg"

The recent Dark Energy Survey Year 1 (DES-Y1) analysis of galaxy cluster abundances and weak lensing produced Ω_{m} and σ_{8} constraints in 5.6σ tension with those derived from Planck. It is suggested in that work that this tension is driven by unmodeled systematics in optical cluster selection.

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Article Synopsis
  • * A patient with a family history of prion disease showed early signs of FFI, like sleep issues and cognitive problems, yet standard diagnostic tests (MRI, CSF analysis, EEG) did not reveal typical changes associated with prion diseases.
  • * Genetic testing confirmed the presence of a harmful mutation linked to FFI, leading to a swift decline in health and eventual death, highlighting the need for awareness among healthcare providers to enhance patient management and emotional support for those affected.
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The recently synthesized monolayer fullerene network in a quasi-hexagonal phase (qHP-C) exhibits superior electron mobility and optoelectronic properties compared to molecular fullerene (C), making it highly promising for a variety of applications. However, the microscopic carrier dynamics of qHP-C remain unclear, particularly in realistic environments, which are of significant importance for applications in optoelectronic devices. Unfortunately, traditional methods are prohibitive for capturing the real-time carrier dynamics of such large systems due to their high computational cost.

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Clinical Question: In adult patients with inflammatory bowel disease, inflammatory arthritis (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis), or psoriasis taking biologic drugs, does proactive therapeutic drug monitoring (TDM) improve outcomes as compared with standard care?

Context And Current Practice: Standard care for immune mediated inflammatory diseases includes prescribing biologic drugs at pre-determined doses. Dosing may be adjusted reactively, for example with increased disease activity. In proactive TDM, serum drug levels and anti-drug antibodies are measured irrespective of disease activity, and the drug dosing is adjusted to achieve target serum drug levels, usually within pre-specified therapeutic ranges.

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Developing theoretical understanding of complex reactions and processes at interfaces requires using methods that go beyond semilocal density functional theory to accurately describe the interactions between solvent, reactants and substrates. Methods based on many-body perturbation theory, such as the random phase approximation (RPA), have previously been limited due to their computational complexity. However, this is now a surmountable barrier due to the advances in computational power available, in particular through modern GPU-based supercomputers.

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