A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis.

Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor, antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small-molecule drugs is known that specifically inhibit protein synthesis in eukaryotic cells. Many of them are well-studied ribosome-targeting antibiotics that block translocation, the peptidyl transferase center or the polypeptide exit tunnel, modulate the binding of translation machinery components to the ribosome, and induce miscoding, premature termination or stop codon readthrough.

"Flora of Russia" on iNaturalist: a dataset.

Background: The "Flora of Russia" project on iNaturalist brought together professional scientists and amateur naturalists from all over the country. Over 10,000 people were involved in the data collection.

New Information: Within 20 months, the participants accumulated 750,143 photo observations of 6,857 species of the Russian flora.

Cloninger's Temperament Dimensions and Longitudinal Alcohol Use in Early Midlife: A Northern Finland Birth Cohort 1966 Study.

Background: Temperament is theorized to be an important factor contributing to the development of alcohol use disorder, but longitudinal studies on how temperament is related to alcohol use among general population in midlife are scarce. Our aims were to investigate potentially reciprocal associations between temperament and changes in alcohol use from age 31 to 46 using prospective birth cohort data.

Method: Within the Northern Finland Birth Cohort 1966, alcohol use and temperament were studied at ages 31 and 46.

Changes in alcohol use in relation to sociodemographic factors in early midlife.

Objective: To describe changes in alcohol use in relation to employment, education and relationship statuses in a general population sample in early midlife using prospective birth cohort data.

Materials And Methods: In the Northern Finland Birth Cohort 1966 (N=5621) alcohol use was studied in participants at two time points: ages 31 and 46. The total mean consumption was calculated and participants were classified into steady drinkers, increasers and reducers based on the change in consumption between the ages of 31 and 46.

[Aberrometry results of a new IOL model with variable refractive surface].

The article presents the aberrometry results of a new intraocular lens (IOL) model with variable refractive surface of own design. By changing the pressure of silicone oil inside the artificial lens three levels of refractive power were achieved: 17.5D; 20.