Mono-, di- and trimeric binding of a bis-netropsin to DNA.

An unusual 3:1 stoichiometry for complex formation between an elongated bis-netropsin compound and its binding site on DNA has been observed. Circular dichroism measurements distinguish two types of complexes formed between this bis-netropsin and poly[d(A-T)].poly[d(A-T)].

[Interaction of synthetic ligands containing N,4-disubstituted mono- and diphthalimides with DNA].

Nevel synthetic DNA binding ligands containing N,4-disubstituted mono- and diphthalimide fragments and carrying positively charged groups at both ends of the molecules were characterized by various physiochemical methods. All the ligands were shown to have fluorescence maximum at about 460 nm for excitation at 340 nm. Interaction of these compounds with DNA and synthetic polydeoxyribonucleotides was studied using spectrophotometry, CD and fluorescence measurements.