Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol.

Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited to SCVs and function as pro-bacterial organelle.

Plasma transcriptome profile associated with CKD progression.

Introduction: Understanding the molecular signals associated with the progression of kidney disease is vital for risk stratification and targeted treatment. Recent advances in RNA-sequencing technique has enabled us to characterize extracellular transcriptome profiles for precision diagnostics.

Method: We evaluated the plasma mRNA profile of participants exhibiting slow (n=119) and fast (n=119) decline in estimated glomerular filtration rate (eGFR) among the Chronic Renal Insufficiency Cohort (CRIC) in a nested case control study.

Pattern and correlates of Internet gaming disorder among medical students - A cross-sectional study from a tertiary care health institute, Rajasthan.

Background: Internet gaming disorder (IGD) is a global problem associated with several psychological complications, such as insomnia, poor academic performance, and aggression. The present study aimed to explore the pattern and correlates of gaming disorder among a sample of medical college students from India and determine the motivational basis for it.

Materials And Methods: An analytical cross-sectional study was conducted at a medical college in Rajasthan from January 2021 to June 2021 after obtaining approval from the Institutional Ethical Committee.

Deciphering the genotypic diversity and epidemiology of scrub typhus genotypes in India: A systematic review and meta-analysis.

Background: Scrub typhus is a significant cause of Acute Febrile Illness in India and presents a range of clinical manifestations influenced by the genotypes of the causative agent, Orientia tsutsugamushi. Understanding the distribution of these genotypes is crucial for public health planning, diagnostic accuracy, and vaccine development.

Methods: In this systematic review, we analyzed 18 studies from an initial pool of 2013 records identified through database searches following PRISMA guidelines.

Gold-Graphene Quantum Dot Hybrid Nanoparticle for Smart Diagnostics of Prostate Cancer.

Prostate cancer is one of the most prevalent cancers afflicting men worldwide, often detected at advanced stages, leading to increased mortality rates. Addressing this challenge, we present an innovative approach employing electrochemical biosensing for early-stage prostate cancer detection. This study used Indium-Tin Oxide (ITO) as a substrate and a deposited gold-graphene quantum dot (Au-GQD) nanohybrid to establish electrochemical sensing platforms for DNA-hybridization assays.