Gingival crevicular fluid and serum vascular endothelial growth factor: their relationship in periodontal health, disease and after treatment.

Objectives: The levels of vascular endothelial growth factor (VEGF) in gingival crevicular fluid (GCF) correlate well with clinical parameters of periodontal disease. The present study was designed to assess the relationship between clinical parameters and VEGF levels of the GCF from inflammed gingiva, periodontitis sites and treated periodontitis sites, and to correlate them to the serum VEGF levels.

Design: Thirty, gender and age-matched subjects were divided into three groups- health, plaque-induced gingivitis and chronic periodontitis group, based on gingival index score and clinical attachment level.

Gingival crevicular fluid VEGF levels in periodontal health and disease.

Background: Vascular endothelial growth factor (VEGF), a glycoprotein, has attracted attention as a potential inducer of angiogenesis. It is detectable in periodontal tissues within endothelial cells, plasma cells, and macrophages and in junctional, sulcular, and gingival epithelium. In periodontitis patients, the volume of gingival crevicular fluid (GCF) and the total amount of VEGF collected from diseased sites were greater than from clinically healthy sites.