[THE CLINICAL ORGANIZATIONAL SUBSTANTIATION OF NEW TECHNOLOGY OF HOSPITAL PSYCHIATRIC CARE].

The new technology of hospital psychiatric care, developed and implemented in the Mordovia republican clinical hospital, permits resolving problems of hospitalism, lethality, pharmaceutical resistance and others. The essence of this technology is in staging of hospital care under condition of intensification and standardization of curative diagnostic process, implementation of complex approach to treatment of psychiatric disorders. The patient sequentially passes through three stages: intensive diagnostics and intensive treatment (intensive care department, intensive therapy department), supportive therapy (general psychiatric department); rehabilitation measures (curative rehabilitative department).

[Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions].

Experiments on white mice under the model immobilization stress condition showed that a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity, and normalization of the cortisole level. This effect is explained by a complex pharmacological action of all factors on the immune and endocrine mechanisms of the stress pathogenesis.