Publications by authors named "D V Pinakhina"
An association between the () intron variant rs521851 and depression symptoms, as measured by the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), has been recently reported. The role of in depression has been linked to disruptions in the gut-brain axis. In this study, we investigated the association between rs521851 and HADS-D scores in an independent cohort of 380 individuals, consisting of 238 patients with an ICD-10 diagnosis of depression and 142 healthy controls.
View Article and Find Full Text PDFBackground: Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has a transdiagnostic nature and is one of the key symptoms of mood disorders, schizophrenia, addictions, and somatic conditions.
Aim: To evaluate the genetic architecture of anhedonia and its overlap with other mental disorders and somatic conditions.
Article Synopsis
- GCDPipe is a new tool designed to help prioritize risk genes, relevant cell types, and potential drug treatments for complex diseases using data from GWAS and gene expression studies.
- * It effectively identifies disease-related cell types and gene targets, demonstrating utility in inflammatory bowel disease (IBD) and Alzheimer’s disease (AD), as well as schizophrenia.
- * The tool shows promise in linking genetic risk factors with cellular context and known drugs, suggesting potential treatments, such as diuretics, may impact diseases like AD.
[Anhedonia in mood disorders and somatic diseases: results of exploratory Mendelian randomization analysis].
Zh Nevrol Psikhiatr Im S S Korsakova
May 2023
Objective: To conduct an exploratory Mendelian randomization analysis of the causal relationships of anhedonia with a wide range of psychiatric and somatic phenotypes based on the genetic data of participants in a population study.
Material And Methods: This cross-sectional study included 4520 participants, of which 50.4% (=2280) were female.
We present the results of the depression Genome-wide association studies study performed on a cohort of Russian-descent individuals, which identified a novel association at chromosome 7q21 locus. Gene prioritization analysis based on already known depression risk genes indicated as the most probable gene from the locus and potential susceptibility gene for the disease. Brain and gut expression patterns were the main features highlighting functional relatedness of to the previously known depression risk genes.
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