[Role of serum factors in decreasing the reaction of peripheral blood lymphocytes in schizophrenia to PHA stimulation].

The blood serum of schizophrenic patients and three of its studied fractions (gamma-globulins and remaining after elimination of gamma-globulins and ultrafiltrate protein fractions) inhibit the lymphocyte response of normals to PHA stimulation (an increase of the DNA content in cells). An insignificant inhibitor effect in the blood serum of normals was seen only in the protein fraction. The PHA precipitating activity of the blood serum in schizophrenic patients which is mainly connected with its protein fraction is increased by 30%.

[Antigenic composition of protein fractions of the human cerebral cortex extracted by chromatography on DEAE-cellulose].

In fractionating a phosphate protein extract from the human brain cortex on DEAE-cellulose 10 fractions of the basic acid proteins were received. Analyses of these fractions were conducted by the method of disc electrophoresis in polyacridamide gel with dodecylsulphate Na and a subsequent separate staining of the desitograms of proteins and glycoproteins, precipitation in agar gel, immunoelectrophoresis and autoimmunography with the use of labeled I125 antibodies to rabbit gamma-globulin. In the first 2 basic fractions there were brain specific antigens with electrophoretic mobility of the beta2--gamma globulin.

[Role of genetic factors in increasing the serum lactate dehydrogenase activity of schizophrenic patients].

To elucidate the role of genetic factors in the increase of the blood serum LDH activity in schizophrenics', there have been studied 103 patients, 97 first degree nonpsychotic relatives, 58 healthy people and 32 pairs of likesex MZ and DZ twins (schizophrenics and normals). A correlation between the enzyme activity in the probands and their relatives is marked. With the aid of a quantitative estimation of the degree of genetic determination of the studied characteristic and special and twin methods the authors obtained the results fitting the hypothesis of additive polygenic inheritance with threshold manifestation.

[Peripheral blood lymphocyte metabolism in schizophrenic patients].

The lymphocytes in the peripheral blood of schizophrenic patients and normals were parallelly studied for the concentration of pyruvic and lactic acid, LDH activity an succinatedehydrogenase, glutamatoxalate and glutamate-pyruvattransaminase. It was established that in the cells of schizophrenic patients compared to normals there was an increased concentration of pyruvic acid, while the LDH activity was decreased. The remaining indices did not differ from normals.