[Thiotriazoline in the Treatment of Stable Angina Pectoris of II-III Functional Class].

Trimetazidine is a metabolic agent of proven efficacy in improving myocardial ischemia and angina. A comparative international multicenter randomized trial, assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60 mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic ischemic heart disease receiving the first line therapy. The study assessed the efficacy of the two drugs on total exercise duration, time to 1-mm ST segment depression, the number of angina attacks and nitroglycerin tablets consumed amount.

[Thiotriazoline in the Treatment of Stable Angina IIIII Functional Class].

Trimetazidine is a metabolic agent of proven efficacy in improving myocardial ischemia and angina. A comparative international multicenter randomized trial, assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60 mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic ischemic heart disease receiving the first line therapy. The study assessed the efficacy of the two drugs on total exercise duration, time to 1-mm ST segment depression, the number of angina attacks and nitroglycerin tablets consumed amount.

[Residual hyperten sion and myocardial hypertrophy in patients operated on for acromegalia].

То study a role of hemodynamic and humoral factors in the development of arterial hypertension and myocardial hypertrophy, 20 and 21 patients with acromegalia were examined before and in the late periods after radical surgical treatment, respectively, for growth hormone-producing pituitary adenoma. The patients underwent blood pressure and central hemodynamic measurements, echocardiography, and some hormones testing at rest and after antiorthostatic tests and exercises. In patients with acromegalia, arterial hypertension occurring in the late postoperative periods was ascertained to be associated with higher vascular resistance, exhausted depressor prostaglandin system, impaired aldosterone and Cortisol reactivity, and insulin hypertension.