[Human serum albumin modified under oxidative/halogenative stress enhances luminol-dependent chemiluminescence of human neutrophils].

It is shown that human serum albumin, previously treated with HOCl (HSA-Cl), enhances luminol-dependent chemiluminescence of neutrophils activated by phorbol-12-myristate-13-acetate (PMA). The enzyme-linked immunosorbent assay revealed that addition of HSA-Cl to neutrophils promotes exocytosis of myeloperoxidase. Inhibitor of myeloperoxidase--4-aminobenzoic acid hydrazide, without any effect on lucigenin-dependent chemiluminescence of neutrophils stimulated with PMA, effectively suppressed luminol-dependent chemiluminescence (IC50 = 20 microM) under the same conditions.

[Prophylaxis and medical rehabilitation of patients presenting with soft tissue diseases].

Soft tissue diseases are pathologic conditions underlain by degenerative, dystrophic, and inflammatory processes developing in muscles, ligaments, synovial bursae and sheaths, fascias, and aponeuroses. Their prevention and medical rehabilitation are achieved with the help of various methods targeted toward different pathogenetic mechanisms and factors facilitating recovery of the affected structures. These methods include instrumental physiotherapy, balneotherapy, peloidotherapy, therapeutic exercises, massage, and pharmacotherapy as appropriate.