Publications by authors named "D V Elverfeldt"
Article Synopsis
- The study addresses high failure rates in cerebrospinal fluid (CSF) shunts, particularly focusing on malfunctioning regulating valves, and aims to improve understanding and analysis of valve failures to minimize unnecessary surgeries.
- It introduces innovative radiological techniques, such as low-dose contrast-enhanced radiography and machine learning, to diagnose valve obstructions more accurately and efficiently.
- The results indicate that these advanced imaging methods and machine learning can effectively analyze fluid transport and identify obstruction mechanisms, paving the way for improved clinical applications and potential repair methods for malfunctioning valves.
Hyperpolarized contrast agents (HyCAs) have enabled unprecedented magnetic resonance imaging (MRI) of metabolism and pH in vivo. Producing HyCAs with currently available methods, however, is typically time and cost intensive. Here, we show virtually-continuous production of HyCAs using parahydrogen-induced polarization (PHIP), without stand-alone polarizer, but using a system integrated in an MRI instead.
View Article and Find Full Text PDFHomo and heterozygote cx3cr1 mutant mice, which harbor a green fluorescent protein (EGFP) in their cx3cr1 loci, represent a widely used animal model to study microglia and peripheral myeloid cells. Here we report that microglia in the dentate gyrus (DG) of cx3cr1 (-/-) mice displayed elevated microglial sirtuin 1 (SIRT1) expression levels and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) p65 activation, despite unaltered morphology when compared to cx3cr1 (+/-) or cx3cr1 (+/+) controls. This phenotype was restricted to the DG and accompanied by reduced adult neurogenesis in cx3cr1 (-/-) mice.
View Article and Find Full Text PDFIntroduction: Lung cancer is the leading cause of cancer-related death worldwide. Small cell lung cancer (SCLC) is thereby a highly aggressive neuroendocrine carcinoma representing about 15% of all lung cancer cases. Due to the highly metastatic behavior and multidrug resistance, the long-term survival of patients is very low.
View Article and Find Full Text PDFPurpose: To evaluate the ability of conventional and ultra-short or zero echo time MRI for imaging of soft and solid dental components in and ex vivo.
Materials And Methods: Turbo spin echo (TSE), ultra-short echo time (UTE), and zero echo time (ZTE) MRI were performed on extracted (human and equine) teeth and in vivo using whole-body and small-bore MR systems at 3 T, 7T, and 9.4T, respectively.