Impact of the Angiotensin-Converting Enzyme (ACE) Inhibitors on the Course of the Acute Respiratory Distress Syndrome (ARDS) Developed During COVID-19 and Other Severe Respiratory Infections Under Hyperferritinemia Conditions: A Cohort Study.

Background: Angiotensin-converting enzyme 2 (ACE2) is not only the entry route of SARS-CoV-2 infection but also triggers a major mechanism of COVID-19 aggravation by promoting a hyperinflammatory state, leading to lung injury, hematological and immunological dysregulation. The impact of ACE2 inhibitors on the course of COVID-19 is still unclear. The effect of ACE2 inhibitors on the course of acute respiratory distress syndrome (ARDS) during COVID-19 and other severe respiratory infections in conditions of hyperferritinemia (HF) was investigated.

DEVELOPMENT OF NEW APPROACHES TO THE TREATMENT OF HEMANGIOMAS IN EXPERIMENT.

The aim of the study was to determine the endogenous factors regulating angiogenesis and develop new approaches to the treatment of uncontrolled growth of capillaries. The effect of a cell proliferation inhibiting thermostable protein complex (TPC), isolated from adult chicken liver, on an experimental model of Hemangioma (adolescent chicken comb) was studied. It has been proved that thermostable proteins isolated from the liver of adult chicken have the ability to inhibit the growth of adolescent bird comb.

ISOLATION AND COMPERATIVE STUDY OF THE GROWTH INHIBITING THERMOSTABLE PROTEIN COMPLEX FROM THE BONE MARROW OF THE ADULT MICE.

The growth inhibiting thermostable protein complex (TPC) from the bone marrow cells of adult mice was isolated and partially characterized. A comparative analysis of TPC components was performed by polyacrylamide gel electrophoresis. It has been established that the complex isolated from the bone marrow of adult mice, like complexes obtained from other organs, contains two relatively high-molecular-weight and low-molecular-weight sub fractions of proteins.

PECULIARITIES OF ACTIVATION OF COMPENSATORY-ADAPTIVE PROCESSES IN ADULT RAT LIVER CAUSED BY UNILATERAL NEPHRECTOMY.

In order to determine the general patterns of activation of the inter organ compensatory-adaptive processes, the peculiarities of activation of compensatory processes caused by unilateral nephrectomy in adult rat liver at the initial stage of hepatopathy (first three days after the operation) have been studied. In particular, it has been established that only small but visible abnormalities in the spatial relationship of sinusoids and hepatic plates are revealed morphologically in rat liver histology. The increasing of the functional load caused by changes in histoarchitecture, at these times, does not stimulate hepatocyte proliferation.

Liver structural transformation after partial hepatectomy and repeated partial hepatectomy in rats: A renewed view on liver regeneration.

Background: The phenomenon of liver regeneration after partial hepatectomy (PH) is still a subject of considerable interest due to the increasing frequency of half liver transplantation on the one hand, and on the other hand, new surgical approaches which allow removal of massive space-occupying hepatic tumors, which earlier was considered as inoperable. Interestingly, the mechanisms of liver regeneration are extensively studied after PH but less attention is paid to the architectonics of the regenerated organ. Because of this, the question "How does the structure of regenerated liver differ from normal, regular liver?" has not been fully answered yet.