Publications by authors named "D V Denisova"
Non-conventional snake venom toxins, such as WTX from the cobra Naja kaouthia, are three-finger proteins containing a fifth disulfide bond in the N-terminal polypeptide loop I and inhibiting α7 and muscle-type nicotinic acetylcholine receptors (nAChRs). Because the central polypeptide loop II of non-conventional toxins plays an important role in their biological activity, we synthesized several WTX loop II fragments with two cysteine residues added at the N- and C-termini and oxidized to form a disulfide bond. The inhibition by peptides of several nAChRs subtypes was investigated using different methods and the effects of peptides on the rat arterial pressure and heart rate were analyzed.
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- - Lung cancer rates in Russia, particularly among men, have declined since the 1990s due to reduced smoking, but recent trends show rising incidence rates, especially in women since 2012, while mortality rates remain stable.
- - The study utilized national cancer reports and the Russian Fertility and Mortality Database from 1965-2021 to analyze changes in lung cancer incidence and mortality, revealing significant shifts starting around 2013 for men and 2012 for women.
- - An increase in the use of CT scans coincides with these trends, suggesting the need for ongoing monitoring to assess the impact of improved diagnostic methods on lung cancer outcomes in Russia.
Article Synopsis
- The study aimed to explore the link between ischemic or nonspecific ECG signs of metabolic changes in the heart and poor cardiovascular outcomes in individuals under 45 over a 7-year period.
- Data was collected from 1,363 young adults in Novosibirsk through a health survey and various biochemical tests, along with resting ECG assessments to identify heart conditions.
- Results indicated a significant association between ECG signs of ischemia and adverse cardiovascular events, with a higher risk recorded for those showing such changes, highlighting the importance of ECG monitoring in young people.
Oligoarginine peptides, known mostly for their cell-penetrating properties, are also inhibitors of the nicotinic acetylcholine receptors (nAChRs). Since octa-arginine (R8) inhibits α9α10 nAChR and suppresses neuropathic pain, we checked if other polycationic compounds containing amino and/or guanidino groups could be effective and tested the activity of the disulfide-fixed "cyclo"R8, a series of biogenic polyamines (putrescine, spermidine, and spermine), -methylated spermine analogs, agmatine and its analogs, as well as acylpolyamine argiotoxin-636 from spider venom. Their inhibitory potency on muscle-type, α7 and α9α10 nAChRs was determined using radioligand analysis, electrophysiology, and calcium imaging.
View Article and Find Full Text PDFBackground: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to have children during this period is thought to be prolonged social stress.
Methods: comparing frequencies of common gene variants associated with stress-induced diseases among generations born before, after, and during this crisis may show which genes may be preferred under the pressure of natural selection during periods of increased social stress in urban populations.